Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strains

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Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein.

Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330...

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Dengue virus type-3 envelope protein domain III; expression and immunogenicity

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Crystal structure of the West Nile virus envelope glycoprotein.

The envelope glycoprotein (E) of West Nile virus (WNV) undergoes a conformational rearrangement triggered by low pH that results in a class II fusion event required for viral entry. Herein we present the 3.0-A crystal structure of the ectodomain of WNV E, which reveals insights into the flavivirus life cycle. We found that WNV E adopts a three-domain architecture that is shared by the E protein...

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Refolding, crystallization and preliminary X-ray structural studies of the West Nile virus envelope (E) protein domain III.

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ژورنال

عنوان ژورنال: Virology

سال: 2005

ISSN: 0042-6822

DOI: 10.1016/j.virol.2005.02.011